iScience - Article Browse Page

Articles

Bhupender Singh

Browse Articles

Showing articles posted by user Bhupender Singh (x)

Synthesis and Anti-HIV Activities of Glutamate and Peptide Conjugates of Nucleoside Reverse Transcriptase Inhibitors
- Posted by Bhupender Singh
- April 11
- 0 comments
- 0 likes
- 196 views
Mono-, di-, and trinucleoside conjugates of glutamate or peptide scaffolds containing nucleoside reverse transcriptase inhibitors were synthesized. Among dinucleoside glutamate ester derivatives, N-myristoylated derivatives showed significantly hi...
Loading of Single-walled Carbon Nanotubes in Cationic Cholesterol Suspensions Significantly Improve Gene Transfection Efficiency in Serum
- Posted by Bhupender Singh
- April 11
- 0 comments
- 0 likes
- 151 views
We present here a series of cholesterol based cationic lipid suspensions that solubilize single-walled carbon nanotubes (SWCNT) efficiently in water. Each cationic lipid formulation was characterized in terms of their energy minimized molecular structu...
Synthesis, Anticancer Activities, and Cellular Uptake Studies of Lipophilic Derivatives of Doxorubicin Succinate
- Posted by Bhupender Singh
- April 11
- 0 comments
- 0 likes
- 279 views
A number of lipophilic 14-substituted derivatives of doxorubicin were synthesized through conjugation of doxorubicin-14-hemisuccinate with different fatty amines or tetradecanol to enhance the lipophilicity, cellular uptake, and cellular retention for ...
CNT loading into cationic cholesterol suspensions show improved DNA binding and serum stability and ability to internalize into cancer cells
- Posted by Bhupender Singh
- February 24
- 1 comment
- 0 likes
- 84 views
Single walled carbon nanotubes were solubilized in water using synthesized Cholesterol lipids and conjugates evaluated for efficacy for oligonucleotide delivery in cancer cells.
Ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene — An efficient and recyclable organocatalyst for Michael addition to α,β-unsaturated ketones
- Posted by Bhupender Singh
- January 25
- 0 comments
- 0 likes
- 215 views
TBD catalyst was supported on Ionic liquid and evaluated for use in Michael reaction.
Ionic Liquid-Supported Synthesis of Sulfonamides and Carboxamides
- Posted by Bhupender Singh
- December 8, 2011
- 4 comments
- 0 likes
- 493 views
Synthesis of ionic liquid supported sulfonamides and carboxamide for application in ionic liquid supported peptides synthesis.
One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their anticancer and Src kinase inhibitory activities
- Posted by Bhupender Singh
- November 9, 2011
- 0 comments
- 0 likes
- 348 views
A number of 2-substituted tetrahydroindazolones were synthesized by three-component condensation reaction of 1,3-diketones, substituted hydrazines, benzaldehydes, and Yb(OTf)3 as a catalyst in [bmim][BF4] ionic liquid using a simple, efficient, an...
3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities
- Posted by Bhupender Singh
- August 15, 2011
- 0 comments
- 0 likes
- 319 views
An efficient and economical method was developed for the synthesis of 3-substituted indoles by one-pot three-component coupling reaction of a substituted or unsubstituted benzaldehyde, N-methylaniline, and indole or N-methylindole using Yb(OTf)3–...
Microwave-Assisted and Scandium Triflate Catalyzed Synthesis of Tetra-hydrobenzo[a]-xanthen-11-ones
- Posted by Bhupender Singh
- August 15, 2011
- 0 comments
- 0 likes
- 658 views
Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones was achieved by one-pot condensation of b-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf)3 under microwave irradiation in excellent isolated yields....
Fatty-Acyl Amide Derivatives of Doxorubicin: Synthesis and In Vitro Anticancer Activities
- Posted by Bhupender Singh
- March 6, 2011
- 0 comments
- 1 like
- 1,138 views
Doxorubicin is an anti-neoplastic drug extensively used in anti-cancer therapy. It is highly hydrophilic with low biological life and have severe side effect with the applied overdoses. Moderation with the introduction of lipophilic group on doxorubici...