Three fatty acyl conjugates of (−)-2′,3′-dideoxy-5-fluoro-3′-thiacytidine (FTC, emtricitabine) were synthesized and evaluated against HIV-1 cell-free and cell-associated virus and compared with the corresponding parent nucleosid...
Doxorubicin conjugates with Cyclic peptide were prepared to improve the cellular membrane permeability and evaluated for anticancer activity against different cell lines.
An improved simple and facile synthesis of chromene derivatives by employing threecomponent one-pot condensation reaction of β-naphthol, aromatic aldehydes, and malononitrile in ionic liquids is described. The ionic liquid can be reused and recycl...
A number of fatty acyl derivatives of (−)-2′,3′-dideoxy-3′-thiacytidine (lamivudine, 3TC, 1) were synthesized and evaluated for their anti-HIV activity. The monosubstituted 5′-O-fatty acyl derivatives of 3TC (EC50 = 0.2–2.3 μM) were more potent than th...
We present here a series of cholesterol based cationic lipid suspensions that solubilize single-walled carbon nanotubes (SWCNT) efficiently in water. Each cationic lipid formulation was characterized in terms of their energy minimized molecular structu...
A number of lipophilic 14-substituted derivatives of doxorubicin were synthesized through conjugation of doxorubicin-14-hemisuccinate with different fatty amines or tetradecanol to enhance the lipophilicity, cellular uptake, and cellular retention for ...
Single walled carbon nanotubes were solubilized in water using synthesized Cholesterol lipids and conjugates evaluated for efficacy for oligonucleotide delivery in cancer cells.
